JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
oleh: Karmveer Singh, Emanuela Camera, Linda Krug, Abhijit Basu, Rajeev Kumar Pandey, Saira Munir, Meinhard Wlaschek, Stefan Kochanek, Marina Schorpp-Kistner, Mauro Picardo, Peter Angel, Catherin Niemann, Pallab Maity, Karin Scharffetter-Kochanek
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
Epidermal homeostasis is maintained by the activity of stem cells. Here, the authors show that deficiency of the transcription factor JunB leads to altered Notch signaling in stem cells, resulting in a cell fate switch and de novo formation of aberrant sebaceous glands, altered epidermal differentiation and impaired barrier function.