Genome-wide analysis in <i>Drosophila</i> reveals diet-by-gene interactions and uncovers diet-responsive genes
oleh: Deanne Francis, Shila Ghazanfar, Essi Havula, James R Krycer, Dario Strbenac, Alistair Senior, Annabel Y Minard, Thomas Geddes, Marin E Nelson, Fiona Weiss, Jacqueline Stöckli, Jean Y H Yang, David E James
| Format: | Article |
|---|---|
| Diterbitkan: | Oxford University Press 2021-05-01 |
Deskripsi
AbstractGenetic and environmental factors play a major role in metabolic health. However, they do not act in isolation, as a change in an environmental factor such as diet may exert different effects based on an individual’s genotype. Here, we sought to understand how such gene–diet interactions influenced nutrient storage and utilization, a major determinant of metabolic disease. We subjected 178 inbred strains from the DrosophilaCG4607