Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility
oleh: Nai-Pin Lin, Nai-Pin Lin, Nan Zheng, Landa Purushottam, Yi Wolf Zhang, Yi Wolf Zhang, Danny Hung-Chieh Chou, Danny Hung-Chieh Chou
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2022-03-01 |
Deskripsi
Glucose-responsive insulin represents a promising approach to regulate blood glucose levels. We previously showed that attaching two fluorophenylboronic acid (FPBA) residues to the C-terminal B chain of insulin glargine led to glucose-dependent solubility. Herein, we demonstrated that relocating FPBA from B chain to A chain increased the baseline solubility without affecting its potency. Furthermore, increasing the number of FPBA groups led to increased glucose-dependent solubility.