Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
oleh: Sheena Dass, Serena Shunmugam, Laurence Berry, Christophe-Sebastien Arnold, Nicholas J. Katris, Samuel Duley, Fabien Pierrel, Marie-France Cesbron-Delauw, Yoshiki Yamaryo-Botté, Cyrille Y. Botté
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-05-01 |
Deskripsi
Apicomplexa generate essential lipids as combination of host fatty acids and de novo synthesized within the apicoplast. Here, the authors identify a phosphatidic acid phosphatase in Toxoplasma gondii, TgLIPIN, as central for controlled lipid synthesis and define the host-scavenged lipidome.