Vitamins and carotenoids in the dynamics of prostate gland oncogenesis
oleh: P. V. Glybochko, E. G. Zezerov, Yu. G. Alyaev, V. B. Spirichev, D. V. Butnaru, S. E. Severin, A. Z. Vinarov, N. A. Beketova, O. G. Pereverzeva, V. A. Varshavsky, E. V. Osipov, E. A. Bezrukov
| Format: | Article |
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| Diterbitkan: | Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) 2022-12-01 |
Deskripsi
The content of vitamins and relative biologically active substances including the products of lipids peroxidation has been studied in the blood of 115 males -patients of Department of Urology of I.M.Sechenov First Moscow State Medical University. The patients have been divided to four groups: prostatic carcinoma (PC); high grade prostatic intraepithelial neoplasia (HG PIN) or precancer; mixed group of conditional control – low grade PIN, benign prostatic hyperplasia, chronic prostatitis or their combination; control group of healthy men without prostate pathology. Further statistically reliable differences have been found: patients with PC had lower level of antioxidants – lycopene, vitamin E and enhanced level of diene conjugates (products of lipid peroxidation); patients with HG PIN low level of vitamin C, total carotenoids and increased diene conjugates. The difference in vitamins-antioxidants levels in patients with PC and HG PIN has not been found out.