Find in Library

A practical, simple, and efficient method for the synthesis of polysubstituted dihydropyridines was described via multi-component reactions of aldehydes, arylamines, dimethyl acetylenedicarboxylate and  malononitrile/ethylacetoacetate in the presence of Fe3O4@SiO2-NH2 nanocomposites. The present methodology provides a novel and efficient method for the synthesis of dihydropyridine derivatives with some advantageous such as excellent yields, short reaction times, recoverability and low catalyst loading. The nanomagnetic catalyst could be readily recovered using an external magnet and reused several times without any significant loss in activity. The catalyst was fully characterized by FT-IR, SEM, XRD, EDX and VSM analysis.