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Anthracycline group of antineoplastic agents is notorious for causing cumulative dose induced cardiotoxicity which is more pronounced in elderly patients and in patients with preexisting cardiac comorbidities. Several preventive strategies have been explored with variable success and without randomized studies and insufficient data. Dexrazoxane is an ethylenediaminetetraacetic acid analog which has been found to be effective when used before or along with anthracycline infusion. The drug is also found to be useful in counteracting injuries caused due to anthracycline extravasation in the tissues.