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<i>Corynebacterium glutamicum</i> is a Gram-positive bacterium (non-spore-forming) that has been wildly used for amino acid production. Due to its stable protein secretion, low extracellular hydrolase activity, and non-toxicity, the application field of <i>C. glutamicum</i> has been greatly expanded. Currently, gene editing technology based on synthetic biology has great potential for synthetic biology research and genetic modification in <i>C. glutamicum</i> because of its ability to efficiently regulate the physiological and metabolic networks of the strain. Therefore, we summarize the gene editing tools and strategies of <i>C. glutamicum</i> from the aspects of genetic modification and expression elements, and we also describe the effects of gene editing techniques on a variety of products such as amino acids and their derivatives, recombinant proteins, and functional sugars, which provide a certain theoretical basis for the research on the modification of <i>C. glutamicum</i> strains and industrial applications. Finally, we prospect the design and industrial application of <i>C. glutamicum</i> genetic modification from multiple perspectives based on gene editing techniques.