Epigenetic control of cellular crosstalk defines gastrointestinal organ fate and function

oleh: Ryan J. Smith, Minggao Liang, Adrian Kwan Ho Loe, Theodora Yung, Ji-Eun Kim, Matthew Hudson, Michael D. Wilson, Tae-Hee Kim

Format: Article
Diterbitkan: Nature Portfolio 2023-01-01

Deskripsi

Mesenchymal-epithelial crosstalk plays a key role in gut development and stem cell homeostasis, though underlying mechanisms are still unclear. Here, the authors demonstrate that mesenchymal Polycomb Repressive Complex 2 controls niche signals for gut epithelial fate and growth.