NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines
oleh: Yuli He, Huayue Song, Jian Chen, Shaolin Zhu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Chiral benzylamines are found in many pharmacologically active molecules. Here, the authors report an enantio- and regio-selective reductive hydroarylation of N-acyl enamines with a NiH/chiral bis-imidazoline catalytic system affording a range of enantioenriched benzylamines.