Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension
oleh: Patrick Wu, QiPing Feng, Vern Eric Kerchberger, Scott D. Nelson, Qingxia Chen, Bingshan Li, Todd L. Edwards, Nancy J. Cox, Elizabeth J. Phillips, C. Michael Stein, Dan M. Roden, Joshua C. Denny, Wei-Qi Wei
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
Prioritizing drug repurposing candidates for downstream studies remains challenging. Here, the authors present a high-throughput approach to identify and validate drug repurposing candidates, integrating human gene expression, drug perturbation, and clinical data from publicly available resources.