ALK-mediated Na+/H+ exchanger-dependent intracellular alkalinization: does it matter for oncogenesis?
oleh: Francesco Turturro, Michael Driscoll, Ellen Friday, Tomas Welbourne
| Format: | Article |
|---|---|
| Diterbitkan: | Ferrata Storti Foundation 2007-05-01 |
Deskripsi
In this study we investigated the relevance of the oncogenic protein NPM-ALK in regulating cellular pH (pHi) through the modulation of Na+/H+ exchanger 1 (NHE1)-activity and the consequences of pHi pharmacological manipulation in cells expressing NPM-ALK.