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With social progress and diversified development of dietary structure, a high level of uric acid has been caused in human body, leading to an increase in the prevalence of hyperuricemia, gout and metabolic syndrome year by year. At present, the efficacy of western medicine in lowering uric acid is remarkable, but certain adverse reactions may be induced. Hence, the development of natural products of uric acid reduction has gradually become a research hotspot. As a clearing damp and promoting diuresis traditional Chinese medicine, Plantaginis semen is one of the commonly used Chinese medicines for the clinical treatment of hyperuricemia and gout. Modern pharmacological studies have confirmed the main chemical components can reduce uric acid level by inhibiting the activity of xanthine oxidase and suppressing uric acid transporter. In this article, the chemical components and uric acid-lowering effect of Plantaginis semen were reviewed.