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The paper discusses the role of anthropological arguments in contemporary ethics as exemplified in the current debate about biotechnological human enhancement interventions. Anthropological arguments refer to a normative conception of what it means to be a human being and are highly contested in contemporary moral philosophy. Most often they are promoted to constrain the ethically acceptable use of enhancement technologies. I argue that anthropological arguments can play a fundamental and important role in assessing the moral qualities of enhancement interventions, but only if their normative justification and their specific content are properly determined. I offer an account how to do so, based on the contractualist and pragmatist ideal that all those who are affected by a decision of normative relevance should be included in what I call a “quasi-democratic deliberative process”. However, given that they stand in need of wide agreement, anthropological arguments resulting from such a process will be rather minimal in content. In the exemplary debate about human enhancements they hence turn out to be widely – though not fully – permissive and unable to justify a restrictive stance towards enhancement interventions.