Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons
oleh: Sun-Gyun Kim, Suho Lee, Yangsik Kim, Jieun Park, Doyeon Woo, Dayeon Kim, Yan Li, Wangyong Shin, Hyunjeong Kang, Chaehyun Yook, Minji Lee, Kyungdeok Kim, Junyeop Daniel Roh, Jeseung Ryu, Hwajin Jung, Seung Min Um, Esther Yang, Hyun Kim, Jinju Han, Won Do Heo, Eunjoon Kim
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-05-01 |
Deskripsi
Alterations of the mTOR signalling pathway are associated with neurodevelopmental defects. Regulators of the mTOR kinase activity are not fully described. Here, the authors show that Tanc2, a scaffolding protein, acts as a direct inhibitor of mTOR kinase activity in the developing mouse brain and cultured human neurons.