Reversible induction of mitophagy by an optogenetic bimodular system
oleh: Pasquale D’Acunzo, Flavie Strappazzon, Ignazio Caruana, Giacomo Meneghetti, Anthea Di Rita, Luca Simula, Gerrit Weber, Francesca Del Bufalo, Luisa Dalla Valle, Silvia Campello, Franco Locatelli, Francesco Cecconi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
Autophagic degradation of mitochondria (mitophagy) is a key quality control mechanism in cellular homeostasis, and its misregulation is involved in neurodegenerative diseases. Here the authors develop an optogenetic system for reversible induction of mitophagy and validate its use in cell culture and zebrafish embryos.