Low excitatory innervation balances high intrinsic excitability of immature dentate neurons

oleh: Cristina V. Dieni, Roberto Panichi, James B. Aimone, Chay T. Kuo, Jacques I. Wadiche, Linda Overstreet-Wadiche

Format: Article
Diterbitkan: Nature Portfolio 2016-04-01

Deskripsi

Immature dentate gyrus neurons are highly excitable and are thought to be more responsive to afferent activity than mature neurons. Here, the authors find stimulation of the entorhinal cortex paradoxically generates spiking in mature rather than immature neurons due to low synaptic connectivity of immature cells.