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Low excitatory innervation balances high intrinsic excitability of immature dentate neurons
oleh: Cristina V. Dieni, Roberto Panichi, James B. Aimone, Chay T. Kuo, Jacques I. Wadiche, Linda Overstreet-Wadiche
Format: | Article |
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Diterbitkan: | Nature Portfolio 2016-04-01 |
Deskripsi
Immature dentate gyrus neurons are highly excitable and are thought to be more responsive to afferent activity than mature neurons. Here, the authors find stimulation of the entorhinal cortex paradoxically generates spiking in mature rather than immature neurons due to low synaptic connectivity of immature cells.