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<p class="p1"><span class="s1"><strong>Purpose: </strong>To conduct a psychometric evaluation of the MENQOL, a condition-specific, self-report instrument to assess menopausal symptoms in women with gynecologic and breast cancers.</span></p><p class="p1"><span class="s1"><strong>Methods: </strong>Identify face and content validity of the MENQOL with experts, and reliability and construct validity with a group of women diagnosed with cancer who are suffering from treatment-induced menopause.</span></p><p class="p1"><span class="s1"><strong>Results:</strong> Eighty-two women with treatment-induced menopause completed the MENQOL, EORTC-C30, and the SVQ. The MENQOL was shown to have good face and content validity, and acceptable reliability (homogeneity and test-retest) and validity (concurrent and construct). Additionally, 85.5% of the women reported experiencing hot flashes. However, the most bothersome symptoms were weight gain and fatigue (feeling worn out).</span></p><p class="p1"><span class="s1"><strong>Implications: </strong>The MENQOL can be used to assess treatment-induced menopausal symptoms in women diagnosed with breast or gynecologic cancer.<span class="Apple-converted-space"> </span></span></p>