Drug-Drug Interactions at Organic Cation Transporter 1
oleh: Shiwei Zhou, Shiwei Zhou, Shiwei Zhou, Sujuan Zeng, Yan Shu, Yan Shu
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2021-02-01 |
Deskripsi
The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.