Structural basis for transthyretin amyloid formation in vitreous body of the eye
oleh: Irina Iakovleva, Michael Hall, Melanie Oelker, Linda Sandblad, Intissar Anan, A. Elisabeth Sauer-Eriksson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
Systemic ATTR amyloidosis causes the abnormal accumulation of ATTR fibrils formed from the human plasma protein transthyretin (TTR) in multiple organs including the eye. Here, the authors present a 3.2 Å cryo-EM structure of an ATTR fibril isolated from the vitreous body of an ATTR patient’s eye and discuss the mechanism for the structural conversion of TTR into a fibrillar form.