A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach
oleh: André C. Sauer, Lucas Wolf, Natália Quoos, Mariele B. Rodrigues, Antônio L. Braga, Oscar E. D. Rodrigues, Luciano Dornelles
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley 2019-01-01 |
Deskripsi
A straightforward and high-yielding methodology for the synthesis of a high structural diversity of 1,2,4-oxadiazoles from different chiral N-protected α-amino acids and amidoximes under microwave (MW) irradiation is described herein. This greener approach gives the desired products using acetone/water as solvent in very short reaction times.