Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification
oleh: Alessandro Magli, June Baik, Pruthvi Pota, Carolina Ortiz Cordero, Il-Youp Kwak, Daniel J. Garry, Paul E. Love, Brian D. Dynlacht, Rita C. R. Perlingeiro
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-05-01 |
Deskripsi
Chromatin looping allows for enhancer–promoter interactions that regulate transcription. Here the authors show that activation of embryonic myogenesis is associated with establishment of long-range chromatin interactions centred on Pax3-bound loci and find that Ldb1 functions as the mediator of looping interactions at a subset of Pax3 binding sites.