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Background: Schizophrenia is a complex mental disorder with a high heritability. Dysfunction of the N-methyl-D-aspartate (NMDA)-type glutamate receptors may be involved in the pathogenesis of schizophrenia. In this study, we examined the contribution of <i>GRIN2A</i> and <i>GRIN2B</i> (Glutamate Ionotropic Receptor NMDA Type Subunit 2A/2B) polymorphisms to the clinical features of schizophrenia, such as the leading symptoms, the type of course, and the age of onset. Methods: A population of 402 Russian patients with schizophrenia from the Siberian region was investigated. Genotyping of seventeen single-nucleotide polymorphisms (SNPs) in <i>GRIN2A</i> and <i>GRIN2B</i> was performed using QuantStudio™ 3D Digital PCR System Life Technologies amplifier using TaqMan Validated SNP Genotyping Assay kits (Applied Biosystems). The results were analyzed using Chi-square and the Fisher’s exact tests. Results: We found an association of <i>GRIN2A</i> rs7206256 and rs11644461 and <i>GRIN2B</i> rs7313149 with the early onset (before the age of 18 years old) schizophrenia. We did not reveal any associations of <i>GRIN2A</i> and <i>GRIN2B</i> polymorphisms with leading (positive vs. negative) symptoms or type of course (continuous vs. episodic) of schizophrenia. Conclusions: In the study, we confirmed the involvement of the <i>GRIN2A</i> and <i>GRIN2B</i> genes in the early onset of schizophrenia in a Russian population of the Siberian region.