Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB
oleh: Jurriaan E.M. de Steenwinkel, Marian T. ten Kate, Gerjo J. de Knegt, Kristin Kremer, Rob E. Aarnoutse, Martin J. Boeree, Henri A. Verbrugh, Dick van Soolingen, Irma A.J.M. Bakker-Woudenberg
| Format: | Article |
|---|---|
| Diterbitkan: | Centers for Disease Control and Prevention 2012-04-01 |
Deskripsi
To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype’s association with multidrug-resistant tuberculosis.