Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
oleh: Jeremie Vitte, Fuying Gao, Giovanni Coppola, Alexander R. Judkins, Marco Giovannini
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-08-01 |
Deskripsi
SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 gene inactivation causes shwannomas.