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With the release of the new Mechanistic-Empirical Pavement Design Guide (MEPDG) in the USA, there is a big shift in pavement analysis and design and many state highway agencies are undertaking initiatives to implement the MEPDG. The Iowa Department of Transportation (DOT) is one such highway agency in the USA interested in implementing the MEPDG. In order to effectively and efficiently transition to the MEPDG from the current empirical approach and accelerate its adoption, the Iowa DOT needs a detailed implementation and training strategy. In support of the MEPDG implementation initiatives, sensitivity studies were conducted using the MEPDG software to identify design inputs pertaining to flexible pavements that are of particular sensitivity in Iowa. Based on a study of the MEPDG design components, the results of sensitivity analyses and past experience, this paper, which is the second of the two companion papers, presents key initiatives for implementing the MEPDG in Iowa. The need for implementing the MEPDG at Iowa DOT and the results of rigid pavement input parameter sensitivity analysis are discussed in detail in the first paper.