Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

oleh: Shuo Qie, Akihiro Yoshida, Stuart Parnham, Natalia Oleinik, Gyda C. Beeson, Craig C. Beeson, Besim Ogretmen, Adam J. Bass, Kwok-Kin Wong, Anil K. Rustgi, J. Alan Diehl

Format: Article
Diterbitkan: Nature Portfolio 2019-03-01

Deskripsi

A subset of esophageal squamous cell carcinoma harbors dysregulated Fbxo4- cyclin D1 axis. Here, the authors show that the dysregulation of Fbxo4-cyclin D1 leads to mitochondrial dysfunction and glutamine addiction rendering these tumors susceptible to metabolic inhibitors even when resistant to CDK4/6 inhibitors.