Large-scale discovery of protein interactions at residue resolution using co-evolution calculated from genomic sequences
oleh: Anna G. Green, Hadeer Elhabashy, Kelly P. Brock, Rohan Maddamsetti, Oliver Kohlbacher, Debora S. Marks
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
Our understanding of the residue-level details of protein interactions remains incomplete. Here, the authors show sequence coevolution can be used to infer interacting proteins with residue-level details, including predicting 467 interactions de novo in the Escherichia coli cell envelope proteome.