ANTI DIABETIC FLAVANONE COMPOUND FROM THE LEAVES OF Artocarpus communis

oleh: Puspa D.N. Lotulung, Sofa Fajriah, Andini Sundowo, Euis Filaila

Format: Article
Diterbitkan: Department of Chemistry, Universitas Gadjah Mada 2010-06-01

Deskripsi

The Flavanone compound with anti diabetic activity was isolated from ethyl acetate extract of Artocarpus communis leaves using column chromatography techniques. The structure of the flavanone compound was elucidated on the basic of spectroscopic evidence and comparison to published values. This compound, 8-geranyl-4,5,7-trihydroxyflavone, showed strong anti diabetic activity on α-glucosidase inhibition assay with IC50 18.120 µg mL-1.   Keywords: Artocarpus communis, 8-geranyl-4,5,7-trihydroxyflavone, anti diabetic activity