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Globally millions of people are affected by tuberculosis (TB) each year and India has the largest number of TB cases both pulmonary and extrapulmonary. Extrapulmonary TB affecting spleen is quite rare and occurs mostly as a part of miliary tuberculosis in immunocompromised patients. In the Immunocompetent patients, isolated splenic tuberculosis is extremely rare. Herein, we present the case of an immunocompetent female with isolated splenic tuberculosis. [Arch Clin Exp Surg 2018; 7(1.000): 37-40]