Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
oleh: Anlian Zhu, Xin Li, Lili Bai, Gongming Zhu, Yuanyang Guo, Jianwei Lin, Yiwen Cui, Gaofei Tian, Lihe Zhang, Jianji Wang, Xiang David Li, Lingjun Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-11-01 |
Deskripsi
ADP-ribosylated peptides are important molecular tools, however, the lack of effective synthetic methods hinders the access to their complex structures. Here, the authors present a biomimetic α-selective ribosylation reaction coupled with click chemistry ultimately providing a two-step modular synthesis of α-ADP-ribosylated peptides.