Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
oleh: Roni Allaoui, Caroline Bergenfelz, Sofie Mohlin, Catharina Hagerling, Kiarash Salari, Zena Werb, Robin L. Anderson, Stephen P. Ethier, Karin Jirström, Sven Påhlman, Daniel Bexell, Balázs Tahin, Martin E. Johansson, Christer Larsson, Karin Leandersson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-10-01 |
Deskripsi
A reactive tumour stroma is associated with poor prognosis. Here, the authors show that in patients with triple negative breast cancer resident monocytes activate cancer-associated fibroblasts and induce production of CXCL16, which acts as a monocyte chemoattractant, resulting in an amplificatory feedback loop.