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Grave’s Disease (GD), an autoimmune disorder, usually presents as diffuse goitre with involvement of both lobes of the thyroid gland. It is characterised by hyperthyroidism, ophthalmopathy and rarely dermopathy. Involvement of eyes can be unilateral or bilateral, but unilateral involvement of a lobe in a bilobar thyroid gland is very rare. Only 13 cases of unilateral GD have been reported so far. This entity may be missed quite often for thyroid hemiagenesis or hyperfunctioning thyroid nodule. Here, authors present a case of unilateral thyroid lobe involvement in a patient of GD.