ZZ-dependent regulation of p62/SQSTM1 in autophagy

oleh: Yi Zhang, Su Ran Mun, Juan F. Linares, JaeWoo Ahn, Christina G. Towers, Chang Hoon Ji, Brent E. Fitzwalter, Michael R. Holden, Wenyi Mi, Xiaobing Shi, Jorge Moscat, Andrew Thorburn, Maria T. Diaz-Meco, Yong Tae Kwon, Tatiana G. Kutateladze

Format: Article
Diterbitkan: Nature Portfolio 2018-10-01

Deskripsi

The autophagic receptor p62 recognizes arginylated (Nt-R) substrates through its ZZ domain (p62ZZ). Here the authors identify a p62 auto regulatory mechanism and provide structural insights into the selective recognition of Nt-R by p62ZZ and further show that Nt-R binding stimulates p62 oligomerization and macroautophagy.