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Maxillary first molar usually has three roots namely, mesiobuccal, distobuccal, and palatal. The incidence of four canals in maxillary first molar ranges from 50.4% to 95%, the fifth canal is 2.25%, and few authors have reported cases with six and seven canals too. With this varying number of canals and canal configurations, endodontic treatment of the maxillary first molars is always a challenge. This clinical article describes a case report of a maxillary first molar with the unusual anatomy of five root canals and its endodontic management.