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The main goal behind this review article is to explain the utilization of Nano-science in sensing application area. Introducing essential aspects regarding nanotechnology together with the explanation and the categorization of nano-structures, and highlighting the opportunity to improve sensor devices performance using nanotechnology are explained. This review, similarly, highlights the usage of a nanowire as fragment of a sensor by means of the configuration of the field-effect transistor. Quantum-dots and their usage in ocular sensing, essentially in the field of nano-medicine, are well thought-out in this review article also. The latter part in this study is revolved on the merits-demerits and present limitation of nano-sensors.