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In the cation of the title compound, C22H24N3O4+·Cl−, an active ingredient of the anticancer drug also known as Tarceva, the quinazoline ring system is planar within 0.044 (3) Å. The dihedral angle formed by the mean planes of the two six-membered quinazoline rings is 3.2 (1)°. Both N-bound H atoms participate in N—H...Cl bonds, which link the ions into infinite chains running along the b axis. C—H...O interactions involving neighboring cations provide additional stabilization of these aggregates.