CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling
oleh: Caojie Liu, Qiuchan Xiong, Qiwen Li, Weimin Lin, Shuang Jiang, Danting Zhang, Yuan Wang, Xiaobo Duan, Ping Gong, Ning Kang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
CHD7 is chromatin remodeler and mutations of CHD7 are the main cause of CHARGE syndrome. Here the authors show that conditional knockout of Chd7 in bone marrow mesenchymal stem cells (MSCs) and pre-osteoblasts leads to a skeletal system development disorder in mice and upregulated PPAR signaling, disrupting the balance between osteogenic and adipogenic differentiation.