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Introduction:The present study evaluates the relationship between the mode of delivery and the frequency and treatment outcomes of congenital nasolacrimal duct obstruction (CNDO).Methods:The medical records of children who were referred to oculoplasty outpatient clinics due to epiphora and diagnosed with CNDO following ophthalmological examination were reviewed retrospectively. The patients’ demographic characteristics, history of pregnancy and delivery, clinical characteristics of CNDO, and treatment outcomes were evaluated.Results:The study included 167 eyes of 136 patients. The mode of delivery was vaginal in 61 patients (45%) and cesarean section in 75 patients (55%). The patients delivered by cesarean section were assigned to group 1, and those delivered via the vaginal route were assigned to group 2. The mean age (p=0.554), gender distribution (p=0.661), laterality (p=0.075) and mean birth weight (p=0.918) did not differ significantly between the two groups. The success rate of probing did not differ significantly between the two groups (p=0.146).Conclusion:The present study found that the mode of delivery did not affect the frequency of CNDO in babies born at term, and there was also no significant difference in the success rate of probing between the two groups. Although the difference was not statistically significant, the authors found cesarean section to be associated with a higher risk of CNDO.