Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation
oleh: Juliette Ezpeleta, Vincent Baudouin, Zaira E. Arellano-Anaya, François Boudet-Devaud, Mathéa Pietri, Anne Baudry, Anne-Marie Haeberlé, Yannick Bailly, Odile Kellermann, Jean-Marie Launay, Benoit Schneider
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-08-01 |
Deskripsi
Aβ plaques have been detected in brains of patients with prion diseases. Here, using mice, the authors show that prion infection enhances Aβ production via a PDK1-TACE mechanism and that brain deposition of Aβ induced by Aβ seeds co-transmitted with PrPSc contributes to mortality in prion disease.