Acid Suppression Use Among Infants in One Tertiary Children's Hospital in China, 2015–2018: A Retrospective Observational Study
oleh: Yue Zhou, Lina Xu, Haishaerjiang Wushouer, Haishaerjiang Wushouer, Aichen Yu, Ziyue Xu, Chaoyang Chen, Chaoyang Chen, Yimin Cui, Yimin Cui, Yimin Cui, Qinghong Lu, Xiaodong Guan, Xiaodong Guan, Luwen Shi, Luwen Shi
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2021-05-01 |
Deskripsi
Clinical guidelines emphasized that physicians should be cautious when prescribing acid suppressions to infants. Histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) are not approved for use in infants aged below 2 years in China. We investigated H2RA/PPI use in infants aged below 2 years hospitalized between 1st January 2015 and 31st December 2018 in a Chinese tertiary children's hospital. Our study observed that H2RAs/PPIs were frequently prescribed with a prevalence of 4.4% (7,158/162,192). The frequency of PPI use was over two-fold than that of H2RA use (71.9%, 5,148/7,158; 28.1%, 2,011/7,158). H2RAs/PPIs were commonly used to treat infants without digestive system diseases (57.5%, 4,118/7,158). Further studies are urgently needed to evaluate the effectiveness and safety of H2RAs/PPIs in infants.