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Abstract Introduction This problem-based learning discussion (PBLD) provides a case-based opportunity for learners to work through a case of acute pulmonary embolism, a frequently encountered potentially life-threatening condition in the operating room and in the ICU. The PBLD is comprised of a set of learning objectives, a detailed stem question that is punctuated by open-ended and analytical clinical questions designed to test learners' clinical decision-making skills. Also provided are a quiz and a handout providing background material on acute pulmonary embolism, which can be used as the basis of a series of mini-lectures on epidemiology, diagnosis, and management of acute pulmonary embolism. This resource is designed for use in small-group sessions; including but not limited to classroom, roundtable, and meeting group sessions. It has been successfully used with a mixed group of learners, including undergraduate students, residents, fellows, and postgraduate practitioners. Methods The learning objectives stem case and stem questions were delivered to the learners one week prior to meeting. At the end of the session, a short written multiple-choice quiz was delivered to the learners. The answers to the quiz were delivered only after taking the quiz. The answers to the quiz were discussed with the group. At the end of the assembly, learners were asked to anonymously fill out a form to evaluate their experience with this PBLD. The author used this PBLD to teach medical students, residents and fellows participating in the Surgical Intensive Care Unit (SICU). Groups ranged in size from 5 to 10. Results Overall, approximately 80 people participated in this PBLD. Approximately, 60% of learners were residents rotating in the ICU, 25% were medical students, 10% were critical care fellows, and 5% were certified practicing intensivists. Assessment of the PBLD was conducted via an anonymous paper-based survey. Ninety percent of participants responded. Eighty-five percent of respondents rated the PBLD as “excellent. This PBLD was cited as a reason for an ‘outstanding’ evaluation the instructor received for the academic year 2010–2011. Discussion Based on learners' enthusiasm and positive feedback, the instructor is currently preparing a curriculum of PBLDs on similar life-threatening ICU topics to be delivered to trainees during their SICU rotation, with the potential of expanding this protocol to other ICUs. This resource promotes interactive learning about a clinical condition that will be encountered by learners at all levels.