Pre-transplant prognostic factors of long-term survival after allogeneic peripheral blood stem cell transplantation with matched related/unrelated donors

oleh: Sophie Servais, Raphaël Porcher, Alienor Xhaard, Marie Robin, Emeline Masson, Jerome Larghero, Patricia Ribaud, Nathalie Dhedin, Sarah Abbes, Flore Sicre, Gérard Socié, Regis Peffault de Latour

Format: Article
Diterbitkan: Ferrata Storti Foundation 2014-03-01

Deskripsi

Mobilized peripheral blood has become the predominant stem cell source for allogeneic hematopoietic cell transplantation. In this retrospective single center study of 442 patients with hematologic malignancies, we analyzed prognostic factors for long-term survival after peripheral blood stem cell transplantation from HLA-matched related or unrelated donors. To account for disease/status heterogeneity, patients were risk-stratified according to the Disease Risk Index. Five-year overall survival was similar after transplants with matched related and unrelated donors (45% and 46%, respectively; P=0.49). Because donor age ≥60 years impacted outcome during model building, we further considered 3 groups of donors: matched unrelated (aged