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Infection attributable to impaired host immunity is the most commonly reported cause of morbidity and mortality among pancreatic transplant recipients. Among these, tuberculosis (TB) has been reported sporadically. Herein, we present a case illustrating the role of whole-body 18F-fluorodeoxyglucose positron emission tomography/computed tomography in diagnosis and follow-up of peripancreatic abdominal TB in a pancreas-only transplant recipient who presented with unexplained fever.