CTCF controls three-dimensional enhancer network underlying the inflammatory response of bone marrow-derived dendritic cells
oleh: Bobae Yang, Sueun Kim, Woong-Jae Jung, Kyungwoo Kim, Sugyung Kim, Yong-Jin Kim, Tae-Gyun Kim, Eun-Chong Lee, Jung-Sik Joo, Chae Gyu Park, Sumin Oh, Kyung Hyun Yoo, Hyoung-Pyo Kim
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
The role of 3D genome organization is not well understood in the transcriptional regulation of dendritic cells. Here the authors show that activation of dendritic cells in vitro induces dynamic reprogramming of the chromatin looping and enhancer activity linked to changes in gene expression and implicates a role for the chromatin architecture protein CTCF in the inflammatory response of dendritic cells.