Bioactive Lactones from the Mangrove-Derived Fungus <i>Penicillium</i> sp. TGM112
oleh: Meng Bai, Guo-Lei Huang, Rong-Qing Mei, Bin Wang, You-Ping Luo, Xu-Hua Nong, Guang-Ying Chen, Cai-Juan Zheng
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-07-01 |
Deskripsi
Three new lactones penicilactones A−C (<b>1</b>−<b>3</b>) were obtained from the mangrove-derived fungus <i>Penicillium</i> sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo<sub>2</sub>(OAc)<sub>4</sub>-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound <b>1</b> showed antibacterial activity against <i>Staphylococcus aureus</i> with an MIC value of 6.25 μg/mL. Compound <b>2</b> showed insecticidal activity against newly hatched larvae of <i>Culex quinquefasciatus</i> with the LC<sub>50</sub> value of 78.5 (±0.58) μg/mL.