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Background: Hypothyroidism is commonly associated with Diabetes Mellitus Type 2, and can affect glycemic control and alteration of lipid profiles with increase in the downstream end-organ related morbidities. Objectives: To find the changes in parameters of glucose and lipid metabolism in Diabetes Mellitus Type 2 in presence of hypothyroidism before and after replacement therapy with L-thyroxine. Methods: In consecutively diagnosed new patients with Diabetes mellitus Type 2, Thyroid screening was done viz. T3, T4, TSH, fT3, fT4. Then Fasting Plasma glucose (FPG), HbA1c, Total Cholesterol (TC), Triglycerides (TG), Very low-density cholesterol (VLDL), Low-density cholesterol (LDL), High-density cholesterol (HDL) were compared among two study groups viz. in Diabetics with hypothyroidism (n=50) and Diabetics without hypothyroidism (n=50) before and after thyroxine replacement and metabolic parameters were analyzed in relation to euthyroid-euglycemic Control group of healthy volunteers. Results: Mean FPG and HbA1c were significantly higher in Diabetics in presence of hypothyroidism compared to euthyroid diabetics. Lipid profiles were also noted to have been compromised in Diabetics in presence of hypothyroidism. After achievement of euthyroid status and with management of diabetes, diabetics achieved significantly reduced FPG and HbA1c along with significantly normalised lipid profile echelons. Conclusion: Our study suggested that we should have high index of suspicion of association of hypothyroidism in diabetics. We need to improve systems approach of routine thyroid screening as Standard Operative Procedure in patients with Diabetes Mellitus Type 2.