MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis
oleh: Wenyuan Wang, Tonis Org, Amélie Montel-Hagen, Peter D. Pioli, Dan Duan, Edo Israely, Daniel Malkin, Trent Su, Johanna Flach, Siavash K. Kurdistani, Robert H. Schiestl, Hanna K. A. Mikkola
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-08-01 |
Deskripsi
MEF2C is a transcription factor required for B-cell proliferation. Here the authors show that MEF2C is also needed in B-cell development and recovery from stress by inducing expression of DNA repair factors that prevent double stranded breaks and enable VDJ recombination.