A tRNA half modulates translation as stress response in Trypanosoma brucei
oleh: Roger Fricker, Rebecca Brogli, Hannes Luidalepp, Leander Wyss, Michel Fasnacht, Oliver Joss, Marek Zywicki, Mark Helm, André Schneider, Marina Cristodero, Norbert Polacek
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-01-01 |
Deskripsi
Trypanosoma brucei mainly relies on translational regulation to adjust gene expression, but details are unclear. Here the authors show that, under stress conditions, tRNAThr half level increases, associates with ribosomes and polysomes, and stimulates protein synthesis by facilitating mRNA loading.