Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma
oleh: Dan Tian, Lu Yang, Song Wang, Yanbing Zhu, Wen Shi, Chunpan Zhang, Hua Jin, Yue Tian, Hufeng Xu, Guangyong Sun, Kai Liu, Zhongtao Zhang, Dong Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
Allergic asthma symptoms may be controlled, but currently no effective therapy exist to address the underlying pathology. Here the authors show, using mouse model of adoptive cell transfer, that CD4-CD8- T cells can suppress the function of dendritic cells and T follicular helper cells via Lag3 to provide allergen-specific protection from asthma.